UPPER Extremity Pain by Region
Most Common to Least Common
UPPER Extremity Pain by Region
Most Common to Least Common
NECK/CERVICAL SPINE
Cervical Radiculopathy
History: Neck pain radiating to arm; numbness in dermatomal pattern
Exam: Positive Spurling test; dermatomal weakness and reflex changes
Tests: MRI cervical spine; EMG/NCS if diagnosis uncertain
Treatment: NSAIDs, PT, epidural steroid injection, surgery if refractory
Cervical Myelopathy
History: Gait imbalance, hand clumsiness, bilateral arm numbness
Exam: Hyperreflexia, Hoffmann sign, Lhermitte sign, gait ataxia
Tests: MRI cervical spine with cord signal changes
Treatment: Surgical decompression; conservative care rarely sufficient
SHOULDER/PERISCAPULAR
Rotator Cuff Tendinopathy/Tear
History: Lateral shoulder pain worse with overhead activity; night pain
Exam: Painful arc, positive empty can and Neer impingement tests
Tests: Ultrasound or MRI shoulder; radiographs for bony pathology
Treatment: PT, NSAIDs, subacromial injection, surgical repair if torn
Adhesive Capsulitis (Frozen Shoulder)
History: Progressive shoulder stiffness and pain; diabetes/thyroid association
Exam: Global restriction of passive ROM, especially external rotation
Tests: Clinical diagnosis; MRI to exclude other pathology
Treatment: PT, intra-articular corticosteroid, manipulation under anesthesia if refractory
Acromioclavicular Osteoarthritis
History: Superior shoulder pain localized to AC joint; worse cross-body
Exam: AC joint tenderness; painful cross-body adduction test
Tests: Radiographs; diagnostic AC joint injection confirms source
Treatment: Activity modification, NSAIDs, AC joint injection, distal clavicle excision
Thoracic Outlet Syndrome (Neurogenic)
History: Arm pain/paresthesias worsened by overhead activity; hand weakness
Exam: Positive Roos/EAST test; Adson test; hand intrinsic atrophy
Tests: EMG/NCS, MRI neurography, diagnostic scalene block
Treatment: PT with postural correction; surgical decompression if refractory
Suprascapular Neuropathy
History: Deep posterior shoulder pain; weakness in external rotation/abduction
Exam: Infraspinatus/supraspinatus atrophy; weak external rotation
Tests: EMG/NCS; MRI to exclude ganglion cyst at spinoglenoid notch
Treatment: PT, activity modification; surgical cyst excision if compressive
Parsonage-Turner Syndrome (Neuralgic Amyotrophy)
History: Sudden severe shoulder pain followed by rapid weakness/atrophy
Exam: Patchy weakness in shoulder girdle; scapular winging possible
Tests: EMG/NCS at 3–4 weeks; MRI to exclude structural lesion
Treatment: Pain management, PT; most recover spontaneously over months
UPPER ARM
Biceps Tendinopathy
History: Anterior shoulder/arm pain worse with lifting and overhead activity
Exam: Tenderness at bicipital groove; positive Speed and Yergason tests
Tests: Ultrasound or MRI; clinical diagnosis usually sufficient
Treatment: NSAIDs, PT, corticosteroid injection, tenodesis if refractory
Radial Nerve Palsy (Saturday Night Palsy)
History: Wrist/finger drop after prolonged arm compression; forearm numbness
Exam: Weak wrist/finger extension; sensory loss dorsal hand
Tests: EMG/NCS localizes at spiral groove; imaging if fracture suspected
Treatment: Cock-up wrist splint, PT; nearly 100% recovery at 6 months
Axillary Neuropathy
History: Lateral shoulder numbness/weakness after dislocation or surgery
Exam: Deltoid weakness; sensory loss regimental badge area
Tests: EMG/NCS at 3–4 weeks; MRI if mass suspected
Treatment: PT, serial monitoring; surgical exploration if no recovery by 3–4 months
ELBOW
Lateral Epicondylitis (Tennis Elbow)
History: Lateral elbow pain with gripping; worse with wrist extension
Exam: Tenderness at lateral epicondyle; pain on resisted wrist extension
Tests: Clinical diagnosis; ultrasound/MRI only if refractory or uncertain
Treatment: Eccentric exercises, counterforce brace, injection, surgery if refractory
Medial Epicondylitis (Golfer's Elbow)
History: Medial elbow pain with gripping; worse with wrist flexion/pronation
Exam: Tenderness at medial epicondyle; pain on resisted wrist flexion
Tests: Clinical diagnosis; rule out ulnar neuropathy with EMG if needed
Treatment: Eccentric exercises, counterforce brace, injection, surgery if refractory
Cubital Tunnel Syndrome (Ulnar Nerve at Elbow)
History: Ring/small finger numbness; worse with elbow flexion; night symptoms
Exam: Positive Tinel at cubital tunnel; weak finger abduction/Froment sign
Tests: EMG/NCS confirms; ultrasound for subluxation or mass
Treatment: Elbow pad, night splint, activity modification; decompression/transposition if refractory
Pronator Syndrome (Median Nerve at Elbow)
History: Volar forearm aching; thumb/index/middle finger paresthesias; rare nocturnal symptoms
Exam: Tenderness over pronator teres; pain with resisted pronation
Tests: EMG/NCS; MRI if space-occupying lesion suspected
Treatment: Rest, NSAIDs, splinting; surgical decompression if no improvement at 3–4 months
WRIST/HAND
Carpal Tunnel Syndrome (Median Nerve at Wrist)
History: Nocturnal hand numbness/tingling in first three digits; shaking relieves
Exam: Positive Durkan compression and Phalen tests; thenar atrophy late
Tests: Clinical diagnosis; EMG/NCS if uncertain or pre-surgical
Treatment: Nighttime neutral wrist splint, injection; carpal tunnel release if refractory
De Quervain Tenosynovitis
History: Radial wrist pain worse with thumb use; gripping, lifting aggravates
Exam: Positive Finkelstein test; tenderness over first dorsal compartment
Tests: Clinical diagnosis; ultrasound if uncertain
Treatment: Thumb spica splint, NSAIDs, corticosteroid injection; surgical release if refractory
Trigger Finger
History: Painful clicking/locking of finger with flexion/extension; morning stiffness
Exam: Palpable tender nodule at A1 pulley; locking with flexion
Tests: Clinical diagnosis; no imaging needed
Treatment: Corticosteroid injection (first-line), NSAIDs; A1 pulley release if refractory
Thumb CMC (Basilar Joint) Arthritis
History: Thumb base pain with pinching, gripping, or turning objects
Exam: Dorsoradial prominence; positive grind test and traction-shift test
Tests: Radiographs of thumb CMC joint; clinical diagnosis
Treatment: Thumb spica splint, NSAIDs, injection; surgical reconstruction if refractory
Ulnar Neuropathy at Wrist (Guyon Canal/Cyclist's Palsy)
History: Hand weakness and ring/small finger numbness; cycling or handlebar pressure
Exam: Intrinsic hand atrophy; positive Froment sign; Tinel at Guyon canal
Tests: EMG/NCS localizes at wrist; ultrasound/MRI if mass suspected
Treatment: Activity modification, padding; surgical decompression if structural cause
Posterior Interosseous Nerve Syndrome
History: Finger extension weakness without sensory loss; forearm aching
Exam: Weak finger/thumb extension; intact wrist extension (ECRL spared)
Tests: EMG/NCS; MRI to exclude compressive mass
Treatment: Rest, splinting, NSAIDs; surgical decompression if no improvement at 3–4 months
VASCULAR
Upper Extremity DVT (Paget-Schroetter Syndrome)
History: Acute arm swelling, pain, cyanosis; often young, active patients
Exam: Arm edema, dilated collateral veins over chest/shoulder
Tests: Duplex ultrasound; CT/MR venography if equivocal
Treatment: Anticoagulation; catheter-directed thrombolysis, first rib resection if TOS-related
Subclavian Artery Stenosis/Steal
History: Arm claudication with exertion; dizziness with ipsilateral arm exercise
Exam: Asymmetric arm blood pressures; periclavicular bruit
Tests: Duplex ultrasound; CT/MR angiography for surgical planning
Treatment: Risk factor modification; angioplasty/stenting or surgical bypass
DIFFUSE/SYSTEMIC
Peripheral Neuropathy
History: Distal symmetric numbness/burning in glove distribution; diabetes common
Exam: Reduced vibration/pinprick distally; absent deep tendon reflexes
Tests: Glucose, B12, TSH, SPEP; EMG/NCS if atypical
Treatment: Treat underlying cause; gabapentinoids, duloxetine for neuropathic pain
Complex Regional Pain Syndrome (CRPS)
History: Disproportionate limb pain after injury/surgery; burning, allodynia, swelling
Exam: Skin color/temperature asymmetry; edema, trophic changes, allodynia
Tests: Budapest criteria (clinical); triple-phase bone scan if uncertain
Treatment: PT, mirror therapy, gabapentinoids, sympathetic blocks, psycholog
BUTTOCK/GLUTEAL
Lumbar Radiculopathy
History: Leg pain worse with sitting; numbness in dermatomal pattern
Exam: Positive straight leg raise; dermatomal weakness/reflex changes
Tests: MRI lumbar spine; EMG/NCS if diagnosis uncertain
Treatment: NSAIDs, PT, epidural steroid injections, surgery if refractory
Sacroiliac Joint Dysfunction
History: Buttock pain worse sitting/rising; history of trauma/pregnancy
Exam: Tenderness at PSIS; positive SI provocation tests
Tests: MRI for inflammation; diagnostic SI joint injection
Treatment: PT, NSAIDs, SI joint injection, radiofrequency ablation
Piriformis/Deep Gluteal Syndrome
History: Deep buttock pain worse with prolonged sitting
Exam: Positive FAIR test; active piriformis test reproduces symptoms
Tests: MRI neurography; EMG to localize entrapment
Treatment: Stretching, NSAIDs, piriformis injection, surgical release if refractory
Cluneal Nerve Entrapment
History: Deep aching low back/buttock pain; "pseudo-sciatica" pattern
Exam: Tender points at iliac crest; no motor/sensory deficits
Tests: Diagnostic nerve block with ≥50% pain relief confirms
Treatment: Nerve blocks, neuroablation, surgical decompression if persistent
Ischiofemoral Impingement
History: Deep buttock pain worsened by long-stride activities like running
Exam: Positive long-stride walking test reproduces symptoms
Tests: MRI shows narrowed ischiofemoral space, quadratus femoris edema
Treatment: Activity modification, PT, image-guided injection, rarely surgery
HIP/THIGH
Hip Osteoarthritis
History: Groin/hip aching; worse with prolonged sitting or walking
Exam: Limited internal rotation; pain with flexion and rotation
Tests: Weight-bearing hip radiographs; clinical diagnosis if age >45
Treatment: PT, NSAIDs, intra-articular injection, total hip arthroplasty
Greater Trochanteric Pain Syndrome
History: Lateral hip pain; worse lying on affected side
Exam: Tenderness at greater trochanter; positive Trendelenburg sign
Tests: Clinical diagnosis; ultrasound/MRI if refractory or uncertain
Treatment: PT, NSAIDs, corticosteroid injection, surgical repair if torn
Meralgia Paresthetica
History: Burning/numbness anterolateral thigh; obesity, tight clothing, diabetes
Exam: Sensory loss anterolateral thigh; no motor weakness
Tests: Clinical diagnosis; nerve conduction studies if atypical
Treatment: Weight loss, loose clothing, nerve block, neurectomy if refractory
Obturator/Femoral Neuropathy
History: Medial thigh pain/weakness; post-surgical or pelvic mass
Exam: Weak hip adduction (obturator) or knee extension (femoral)
Tests: EMG/NCS; pelvic MRI to exclude compressive lesion
Treatment: Treat underlying cause; PT, nerve block, surgical decompression
Myofascial Pain
History: Regional aching pain; history of overuse or postural strain
Exam: Palpable trigger points reproducing referred pain pattern
Tests: Clinical diagnosis; no specific confirmatory test needed
Treatment: Trigger point injection, stretching, PT, dry needling
KNEE/LEG
Common Peroneal Neuropathy
History: Foot drop, lateral leg numbness; habitual leg crossing/compression
Exam: Weak ankle dorsiflexion/eversion; sensory loss dorsal foot
Tests: EMG/NCS localizes lesion at fibular head; MRI if mass
Treatment: AFO brace, activity modification, surgical decompression if refractory
Baker Cyst
History: Posterior knee swelling/tightness; not intermittent, worse with activity
Exam: Palpable fullness in popliteal fossa; tenderness present
Tests: Ultrasound confirms cyst; MRI if internal derangement suspected
Treatment: Treat underlying knee pathology; aspiration, injection, excision
Chronic Compartment Syndrome
History: Tight bursting calf pain with strenuous exercise; heavy-muscled athletes
Exam: Firm compartments post-exercise; normal exam at rest
Tests: Intracompartmental pressure measurement pre/post exercise
Treatment: Activity modification; fasciotomy if conservative measures fail
Venous Claudication/DVT
History: Entire leg tightness worse in calf; history of prior DVT
Exam: Leg edema, venous stasis changes; relief with elevation
Tests: Duplex ultrasound; D-dimer if acute DVT suspected
Treatment: Anticoagulation (DVT), compression stockings, leg elevation
PAD/Arterial Claudication
History: Calf cramping with walking; relieved quickly by rest
Exam: Diminished pulses, pallor on elevation, dependent rubor
Tests: Ankle-brachial index; CT/MR angiography if intervention planned
Treatment: Risk factor modification, supervised exercise, revascularization if severe
ANKLE/FOOT
Plantar Fasciitis
History: Plantar heel pain with first steps after rest
Exam: Tenderness at medial calcaneal tuberosity and plantar fascia
Tests: Clinical diagnosis; imaging only to exclude stress fracture
Treatment: Stretching, orthotics, shockwave therapy, corticosteroid injection
Achilles Tendinopathy
History: Pain 2–6 cm above heel insertion; worse with activity
Exam: Tenderness/thickening along midportion Achilles tendon
Tests: Clinical diagnosis; ultrasound/MRI if tear suspected
Treatment: Eccentric strengthening exercises, shockwave therapy, PT
Morton Neuroma
History: Burning forefoot pain radiating to 3rd/4th toes; tight shoes
Exam: Positive Mulder click and Tinel sign at webspace
Tests: Clinical diagnosis; ultrasound/MRI to confirm or exclude other pathology
Treatment: Wide shoes, orthotics, corticosteroid injection, excision if refractory
Tarsal Tunnel Syndrome
History: Burning/tingling medial ankle radiating to sole; worse standing
Exam: Positive Tinel sign posterior to medial malleolus
Tests: EMG/NCS; MRI to identify compressive lesion
Treatment: Orthotics, NSAIDs, neuromodulators, injection, surgical release
Sural Neuropathy
History: Lateral ankle/foot numbness; often post-traumatic or post-surgical
Exam: Sensory loss lateral foot/ankle; no motor deficit
Tests: Nerve conduction studies confirm; ultrasound if mass suspected
Treatment: Activity modification, desensitization, surgical exploration if needed
Peripheral Neuropathy
History: Distal symmetric numbness/burning in stocking distribution; diabetes common
Exam: Reduced vibration/pinprick distally; absent ankle reflexes
Tests: Glucose, B12, TSH, SPEP; EMG/NCS if atypical
Treatment: Treat underlying cause; gabapentinoids, duloxetine for pain