Epidural steroid injections and intramuscular steroid injections do not directly alter the results of electromyography (EMG) or nerve conduction studies (NCS), except in rare cases of procedural complications such as nerve injury or hematoma, which are uncommon and not a routine effect of these interventions.[1-4] The American Academy of Neurology and the American Society of Regional Anesthesia and Pain Medicine both note that the primary adverse effects of epidural steroid injections are related to procedural risks, not to changes in electrodiagnostic parameters.[1-2]
For intramuscular glucocorticoid injections, recent randomized controlled trial data show that while these injections can improve pain and disability in lumbar radicular pain, they do not produce significant changes in EMG or NCS findings compared to placebo. The only observed effect was the disappearance of fibrillation potentials in both treatment and placebo groups, likely reflecting clinical improvement rather than a direct pharmacologic effect on nerve conduction or muscle electrical activity.[5]
Epidural steroid injections may improve clinical symptoms in radiculopathy and spinal stenosis, but they do not acutely change EMG or NCS results. Electrodiagnostic findings are used for diagnosis and prognostication, not for monitoring response to steroid injections, and improvement in symptoms does not necessarily correlate with changes in EMG/NCS parameters.[6-9]
In summary, neither epidural nor intramuscular steroid injections are expected to directly affect EMG or nerve conduction study results, except in rare cases of procedural complications. Clinical improvement after these interventions may be reflected in symptom scores, but not in electrodiagnostic measurements.[1-7][9]
Would you like me to review the literature on how the timing of EMG/NCS relative to steroid injections might influence diagnostic accuracy or interpretation, particularly in cases of recent symptom improvement?
1.
Epidural Steroids for Cervical and Lumbar Radicular Pain and Spinal Stenosis Systematic Review Summary: Report of the AAN Guidelines Subcommittee.
Armon C, Narayanaswami P, Potrebic S, et al.
Neurology. 2025;104(5):e213361. doi:10.1212/WNL.0000000000213361.
New Research
2.
Practice Guidelines for Chronic Pain Management: An Updated Report by the American Society of Anesthesiologists Task Force on Chronic Pain Management and the American Society of Regional Anesthesia and Pain Medicine.
Anesthesiology. 2010;112(4):810-33. doi:10.1097/ALN.0b013e3181c43103.
Practice Guideline
3.
Safeguards to Prevent Neurologic Complications After Epidural Steroid Injections: Consensus Opinions From a Multidisciplinary Working Group and National Organizations.
Rathmell JP, Benzon HT, Dreyfuss P, et al.
Anesthesiology. 2015;122(5):974-84. doi:10.1097/ALN.0000000000000614.
4.
Neurological Complication Rates of Epidural Injections and Selective Nerve Blocks: A Comparison of Steroid Use Patterns.
Hwang B, Lee J, Park BJ.
The Clinical Journal of Pain. 2020;36(6):449-457. doi:10.1097/AJP.0000000000000816.
5.
Efficacy of Intramuscular Glucocorticoid Injection in Patients With Lumbar Radicular Pain: A Randomized Controlled Trial.
Boga Vijdan E, Basaran S, Balal M.
BMC Musculoskeletal Disorders. 2025;26(1):650. doi:10.1186/s12891-025-08897-1.
New Research
6.
Role of Electrodiagnosis in Patients Being Considered for Epidural Steroid Injections.
Annaswamy TM, Bierner SM, Avraham R.
PM & R : The Journal of Injury, Function, and Rehabilitation. 2013;5(5 Suppl):S96-9. doi:10.1016/j.pmrj.2013.03.013.
7.
Are Electrodiagnostic Study Findings Related to a Patient's Response to Epidural Steroid Injection?.
Marchetti J, Verma-Kurvari S, Patel N, Ohnmeiss DD.
PM & R : The Journal of Injury, Function, and Rehabilitation. 2010;2(11):1016-20. doi:10.1016/j.pmrj.2010.07.002.
8.
Predicting Response to Epidural Steroid Injections for Lumbar Spinal Stenosis With Biomarkers and Electromyography.
Lin CK, Borresen A, Kroll M, Annaswamy TM.
PM & R : The Journal of Injury, Function, and Rehabilitation. 2020;12(7):663-670. doi:10.1002/pmrj.12272.
9.
Needle Electromyography Predicts Outcome After Lumbar Epidural Steroid Injection.
Annaswamy TM, Bierner SM, Chouteau W, Elliott AC.
Muscle & Nerve. 2012;45(3):346-55. doi:10.1002/mus.22320.