MEDICAL CANNABIS 

• DEFINITIONS/CONVERSIONS

• BY THE NUMBERS

• RESEARCH STUDIES

ROUTES OF AMINISTRATION: 

Key clinical points (condensed): Inh/SL/Oral [Fast = higher]  approx 20 / 20 or less / 10% 

• Inhalation (smoked/vaped): ~10–35% bioavailability; peaks in 5–10 min. Vaporization is typically more efficient than smoking.[1][2]   Smoking may be 10-20% 

• Sublingual: ~10–20% bioavailability; onset 15–45 min; partially bypasses first-pass metabolism.[3][4]

• Oral: ~4–12% bioavailability due to hepatic metabolism; higher 11-OH-THC formation prolongs effects.[5][6]

• Topical: ~0-1% systemic bioavailability with standard formulations; effects are local.[7]

• Conversion: Inhalation-to-oral ≈2.5× by bioavailability, but clinical effects vary due to metabolism differences.[5]

🌿 Cannabis by the Numbers (Clinical Outline)

1) Weight Conversions

1 oz = 28 g - ½ oz = 14 g |  ¼ oz = 7 g | ⅛ oz = 3.5 g |  1 lb = 448 g

2) Liquid Conversions

1 fl oz = 30 mL • 1 mL ≈ 20 drops • 1 dropper = 1 mL • 1 drop ≈ 0.05 mL

3) Tincture Math (Clinical Use)

mg/mL = total mg ÷ total mL

Common 30 mL bottles:
300 mg → 10 mg/mL • 600 mg → 20 mg/mL • 1000 mg → ~33 mg/mL • 2000 mg → ~66 mg/mL

Dosing

• 1 dropper (1 mL) = mg/mL

• 0.5 mL = half dose

• Drops: mg/mL ÷ 20 = mg/drop

4) Flower / Joint Potency

grams × 1000 × % = total mg THC

Typical joint:

• 0.5 g @ 20% → 100 mg THC total

• Bioavailability inhaled ≈ 10–30% absorbed

5) Edible Doses

5–10 mg (low) • 20–50 mg (strong) • 100+ mg (heavy)

6) Temperature + Time (Real Use)

220°F → ~2 hrs (decarb for edibles)

320 F  = 20-30 MINUTES
420 VAPE = 2 SECONDS/INSTANT. ~400–450°F (combustion/joint) → secs onset
520°F+ → excessive combustion/harsh

7) Key Points

• Inhalation = rapid onset, lower absorption efficiency

• Oral = delayed onset, higher systemic conversion (11-hydroxy-THC)

• Tinctures = intermediate (sublingual vs swallowed)

🧠 Clinical Cases (Q/A)

1. Patient smokes 0.5 g @20%. THC total? → 100 mg

2. Same joint, ~20% absorbed. Systemic THC? → ~20 mg

3. Patient smokes 1 g @15%. THC total? → 150 mg

4. Patient smokes half. THC consumed? → 75 mg

5. 3.5 g @20%. Total THC? → 700 mg

6. Bottle: 30 mL, 900 mg THC. mg/mL? → 30 mg/mL

7. Patient takes 0.5 mL. Dose? → 15 mg

8. Patient takes 10 drops (~0.5 mL). Dose? → ~15 mg

9. Bottle 600 mg/30 mL. mg/drop? → ~1 mg/drop

10. Patient takes 5 drops. Dose? → ~5 mg

11. Bottle: 1:1 THC:CBD, 600 mg total. Each cannabinoid? → 300 mg each

12. Same bottle, 30 mL. mg/mL each? → 10 mg THC + 10 mg CBD

13. Patient takes 1 mL. Dose? → 10 mg THC + 10 mg CBD

14. Patient takes 0.25 mL. Dose? → 2.5 mg each

15. Patient ingests 100 mg edible. Expected intensity? → heavy dose

16. Patient takes 5 mg edible. Expected effect? → low dose

17. Oral onset timing? → 30–120 minutes

18. Inhalation onset timing? → seconds–minutes

19. Preparing flower at 220°F. Purpose? → decarboxylation

20. Smoking above ~450°F. Result? → combustion + rapid delivery

1 joint ≈ 0.5 g.
1 g ≈ 2 joints. ⅛ oz (3.5 g) ≈ 7 joints. ¼ oz (7 g) ≈ 14 joints.
½ oz (14 g) ≈ 28 joints. 1 oz (28 g) ≈ 56 joints.

At 20% THC: 0.5 g joint = 100 mg THC raw; ~10–30 mg absorbed.
Bowl (~0.25 g) = ~½ joint = 50 mg raw. Blunt (~1 g) = ~2 joints = 200 mg raw.

Daily 1 joint = 14 g/month.
Daily 2 joints = 28 g/month.
Daily 4 joints = 56 g/month.

Flower limit: 2.5 oz (≈70 g) every 35 days, about 140 joints (0.5 g each).
Average ≈2 g/day ≈4 joints/day.

THC products limit: 24,500 mg every 70 days.
Average ≈350 mg/day.

Cycles: 35 days for flower, 70 days for THC.

No home grow. Must purchase from licensed dispensaries.

Tincture (CBD/THC mixed)
Total 500 mg over 30 doses → ~16.7 mg per dose total.
If 1:1 ratio → ~8.3 mg THC + ~8.3 mg CBD per dose.
Clinical use: mild balanced effect.

Tincture (CBD only)
500 mg over 30 doses → 16.7 mg CBD per dose.
0 mg THC.
Clinical use: non-intoxicating, anti-inflammatory/anxiolytic.

RSO syringe (THC)
1000 mg total over 10 doses → 100 mg THC per dose.
Clinical use: very high potency; typically divided further (e.g., 10–20 mg increments).

Summary: 16.7 mg = mild dose; 100 mg = heavy dose.

RSO syringe: 72% THC = 720 mg THC per 1 g syringe |  If labeled 1000 mg total product → ~720 mg THC actual

Dosing (clinical approximations):

• Rice-sized ≈ 0.05 g → ~36 mg THC

• Half rice-sized ≈ 0.025 g → ~18 mg THC

• Quarter rice-sized ≈ 0.01–0.015 g → ~7–11 mg THC

Summary: Half rice ≈ moderate (15–20 mg) Full rice ≈ strong (30–40 mg)

250 mg / 60 mL ≈ 4 mg/mL

Example 1: Pea-sized (~1 mL) on sore joint → ~4 mg
Example 2: Quarter-sized (~5 mL) on large area → ~20 mg

264 mg/mL (topical; very potent)

Example 1: Light fingertip dab (≈0.05 mL) → ~13 mg to small joint  [ 10-15MG ]
Example 2: Small pea-sized (≈0.1 mL) → ~26 mg to localized area [ 25 MG ] 

Decarb.: [TEMP.TIME =  ~220°F (THCA → THC over time)2HR, 300F @ 20-30, 420F FOR SECS)

Terpenes (boiling): ~250–350°F (flavor/aroma vaporize first)

Cannabinoids (boiling): ~315–365°F (THC, CBD vaporize)
Flavonoids (boiling): ~300–400°F (taste/color compounds)

Combustion: ~450°F+ (burning, smoke, toxin formation)